diethyldithiocarbamate

**Diethyldithiocarbamate** is the anionic form of diethyldithiocarbamic acid and is most recognized as the primary metabolite of disulfiram, a drug used in the management of alcohol dependence. It acts as a **chelating agent**, capable of binding soft metal ions and increasing their elimination from tissues in both experimental animals and humans. Diethyldithiocarbamate is used to mobilize toxic metals, has been investigated as an **orphan drug for AIDS**, and studied as an adjunct in various cancer and liver disease research settings. Mechanistically, it is a known **inhibitor of cytochrome P450 2E1** and **nuclear factor kappa-B (NF-κB)**, possessing antioxidant properties and affecting other signaling pathways including those relevant to liver fibrosis. It also exhibits **superoxide dismutase inhibition** and can impact immune cell signaling and response[1][3][5][7][9].

Brand names

Imuthiol

Other names

ditiocarbdiethyl dithiocarbamatediethylcarbamodithioic aciddiethyldithiocarbamic aciddiethyldithiocarbamate iondiethyldithiocarbamate anionDieca