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DiffronC
- Development stage
- Preclinical
- Lead developer
- Regen BioPharma
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Gene Therapies, Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules
01
Overview
DiffronC is an oligonucleotide-based gene therapy developed by Regen BioPharma that utilizes proprietary small interfering RNA (siRNA) technology to induce differentiation of cancer stem cells. Its mechanism involves silencing nuclear receptor targets—specifically those that maintain stem cells in an undifferentiated state—thereby promoting the maturation of blood-forming stem and progenitor cells into functional blood cells. This approach is designed as a differentiation therapy for hematological malignancies such as leukemia and myelodysplastic syndromes where normal cellular maturation is blocked. Preclinical data have demonstrated its ability to drive differentiation in vitro and provide proof-of-concept for its use in treating disorders characterized by impaired blood cell development[8][10][6].
- Brand names
- DiffronC
- Other names
- IDO-silenced cancer immunotherapeutic - Regen BiopharmaNR2F6 inhibitors - Regen BioPharmaNR-2F6 inhibitors - Regen BioPharmaNR 2F6 inhibitors - Regen BioPharmaNR2F6 T cell immunotherapyNR-2F6 T cell immunotherapyNR 2F6 T cell immunotherapyNR2F6-silenced cancer therapeutics - Regen BioPharmaNR-2F6-silenced cancer therapeutics - Regen BioPharmaNR 2F6-silenced cancer therapeutics - Regen BioPharmaucVAXUniversal donor cell therapy - Regen BioPharma
02
Targets
NR2F6 (Nuclear receptor subfamily 2 group F member 6)
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