diftalone

Diftalone is a non-acidic, non-steroidal anti-inflammatory drug (NSAID) belonging to the phthalazino-phthalazine chemical class. Developed by Lepetit, it was primarily investigated and marketed for the treatment of inflammatory and degenerative joint diseases, including rheumatoid arthritis and osteoarthritis (specifically coxarthrosis and gonarthrosis). Diftalone exhibits analgesic, anti-inflammatory, and antipyretic properties. Unlike many traditional acidic NSAIDs, it was noted for a distinct pharmacological profile, although its primary mechanism involves the inhibition of cyclooxygenase enzymes. The drug was marketed under the brand name Aladione but was eventually discontinued or withdrawn from most markets in the late 1970s and early 1980s due to concerns regarding its potential for liver enzyme induction and hepatotoxicity.

Brand names

Aladione

Other names

diftalonediftalonum7H-Phthalazino[2,3-b]phthalazine-5,12-dione