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digoxin immune fab
- Development stage
- Approved
- Lead developer
- Bio-Technology General
- Modality
- Recombinant Proteins and Enzymes, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Digoxin immune fab is an antibody fragment derived from sheep immunized with a digoxin derivative. It consists of antigen-binding fragments (Fab) that specifically bind to and neutralize free digoxin or digitoxin molecules in the bloodstream. By binding these cardiac glycosides, it prevents them from interacting with their physiological target—the sodium-potassium ATPase pump—thereby reversing their toxic effects on the heart. The resulting Fab-digoxin complexes are then cleared by the kidneys and reticuloendothelial system. Digoxin immune fab is used as an antidote for life-threatening overdose or toxicity of digoxin or digitoxin and is administered intravenously in hospital settings[1][2][3][4][5][6][8].
- Brand names
- DigibindDigiFab
- Other names
- digoxin immune fabdigoxin immune fab (ovine)DIF
02
Targets
ATP1A2 (Na+/K+-ATPase alpha-2)
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