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dihydroartemisinin-piperaquine + tafenoquine
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of dihydroartemisinin-piperaquine, an artemisinin-based combination therapy (ACT), and tafenoquine, an 8-aminoquinoline. This combination is used for the radical cure of Plasmodium vivax malaria, targeting both the blood-stage parasites (through dihydroartemisinin-piperaquine) and the hypnozoite forms that cause relapse (through tafenoquine). Clinical studies have shown that while this combination is statistically superior to dihydroartemisinin-piperaquine alone in preventing relapse, the clinical benefit is not as meaningful as expected compared to other combinations like tafenoquine plus chloroquine.
- Other names
- TQ + DHA-PQPTafenoquine plus DHA-piperaquine
02
Targets
PfHDP (Heme detoxification protein (HDP))β-HematinPlasmodium vivax hypnozoite redox homeostasis
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