dihydrocucurbitacin b

Dihydrocucurbitacin B is a naturally occurring cucurbitane triterpenoid isolated from various plants of the Cucurbitaceae family, including *Cayaponia tayuya*, *Wilbrandia ebracteata*, and *Trichosanthes kirilowii*. It exhibits a wide range of pharmacological activities, including anti-inflammatory, immunosuppressive, lipid-lowering, and anticancer properties. Mechanistically, dihydrocucurbitacin B has been shown to selectively inhibit the nuclear factor of activated T cells (NFAT) in human lymphocytes and suppress cyclooxygenase-2 (COX-2) activity. In lipid metabolism, it promotes LDL clearance by upregulating low-density lipoprotein receptor (LDLR) expression and downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9) expression. In oncology models, it induces G2/M cell-cycle arrest and apoptosis, potentially through the downregulation of the PI3K/Akt/mTOR signaling pathway and cyclins such as cyclin B1.

Other names

23,24-dihydrocucurbitacin BDHCBdihydrocucurbitacin B