Drug intelligence / Profile preview

dihydroresveratrol

Development stage
Preclinical
Modality
Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Dihydroresveratrol is a naturally occurring stilbene derivative and a small molecule polyphenol. It is structurally related to resveratrol but differs by the saturation of the ethylene bridge between its phenolic rings. Dihydroresveratrol exhibits antioxidant, anti-inflammatory, antibacterial, and anti-tumor activities. It has been studied for potential use in preparing drugs for cancer, cardiovascular diseases, cerebrovascular diseases, and as an anti-inflammatory agent. Its mechanism of action includes inhibition of leukotriene A4 hydrolase (LTA4H), which plays a role in inflammation by catalyzing the conversion of LTA4 to leukotriene B4 (LTB4), a pro-inflammatory mediator[1][3][5]. Dihydroresveratrol is also used as an antioxidant preservative in food products.

Other names
dihydroresveratrol3,4',5-trihydroxybibenzyl5-(4-hydroxyphenethyl)benzene-1,3-diol
02

Targets

LTA4H (Leukotriene A4 hydrolase)

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