dihydrotachysterol

Dihydrotachysterol is a synthetic analog of vitamin D used primarily to manage conditions associated with low calcium levels such as hypoparathyroidism, rickets, and osteomalacia[1][2][3]. Unlike natural forms of vitamin D that require activation in the kidneys, dihydrotachysterol is activated in the liver to its major circulating form (25-hydroxydihydrotachysterol), making it effective even in patients with impaired renal function[2][7]. Its mechanism involves binding to the vitamin D receptor (VDR), acting as a transcriptional regulator for genes involved in calcium and phosphate homeostasis. This results in increased intestinal absorption of calcium and enhanced renal excretion of phosphate[2][3]. The drug is administered orally and has a slow but persistent effect on serum calcium levels.

Brand names

AT10AT-10AT 10

Other names

9,10-secoergosta-5,7,22-trien-3β-ol