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dihydrotachysterol + microcrystalline calcium hydroxyapatite

Development stage
Preclinical
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination therapy consisting of dihydrotachysterol, a synthetic vitamin D analog, and microcrystalline calcium hydroxyapatite, a bioavailable form of calcium. Dihydrotachysterol acts by increasing intestinal absorption of calcium and mobilizing bone calcium in the absence of parathyroid hormone or functioning renal tissue. Microcrystalline calcium hydroxyapatite provides a source of dietary calcium that is structurally similar to the mineral component of bone. The combination has been studied for use in conditions involving bone demineralization such as osteogenesis imperfecta and osteoporosis, where it can improve positive calcium balance and potentially benefit patients with increased risk for fractures or low bone density[1][2][3].

02

Targets

VDR (Vitamin D receptor)

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