diisopromine

Diisopromine is a small molecule spasmolytic agent that has historically been used for the treatment of hepatobiliary disorders, including biliary dyskinesia and cholecystitis. It acts as a musculotropic spasmolytic, exerting a relaxant effect on the smooth muscles of the biliary tract. More recently, diisopromine has been investigated as a potential non-labeled substrate for the Cytochrome P450 3A4 (CYP3A4) enzyme. Due to its structural similarity to tolterodine and its metabolic pathway—which involves N-dealkylation to produce volatile acetone—it is being developed for use in non-invasive breath tests to assess patient-specific CYP3A4 activity and drug metabolism efficiency. Research indicates that diisopromine is primarily metabolized by CYP3A4, with minor contributions from CYP2D6 and CYP2C9, and exhibits lower cellular toxicity compared to similar substrates.

Brand names

Agofell

Other names

DisopromineN,N-diisopropyl-3,3-diphenylpropylamine