dim-c-pphcl

**DIM-C-pPhCl** is a synthetic small molecule belonging to the class of bis-indole-derived compounds known as C-DIMs. Its chemical name is 1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane. DIM-C-pPhCl acts as a **selective agonist of the orphan nuclear receptor Nurr1 (NR4A2)**, with limited activity on closely related receptors such as Nur77 and Nor1. In cell and animal models, it induces expression of pro-apoptotic and anti-proliferative genes and demonstrates significant antitumor activity, most notably through **activation of Nurr1-dependent transcription** and apoptosis in cancer cells. It has been studied preclinically for antineoplastic properties, including tumor growth inhibition and induction of apoptosis in models of bladder, colon, pancreatic, and other cancers.

Other names

1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methaneC-DIM 12C-DIM12C-DIM-12