dimemorfan

Dimemorfan is a nonnarcotic antitussive (cough suppressant) of the morphinan family, structurally related to dextromethorphan and dextrorphan. It is widely used in Japan and also marketed in Spain and Italy. Dimemorfan acts primarily as a potent agonist of the sigma-1 receptor, with little to no activity at NMDA receptors, which distinguishes it from dextromethorphan by reducing dissociative side effects and abuse potential. Its antitussive effect appears to be mediated by direct action on the cough center in the medulla rather than through opioid receptors. Clinical studies indicate that it is as effective or more effective than codeine or dextromethorphan for suppressing cough, with a low incidence of adverse events such as nausea, somnolence, dry mouth, and decreased appetite. Dimemorfan has also demonstrated anti-inflammatory properties via sigma-1 receptor-independent mechanisms involving inhibition of NADPH oxidase activity and NF-kappaB signaling pathways[1][3][4][6].

Brand names

AstominDastosirrTusben

Other names

dimemorphandimemorfan phosphate