Drug intelligence / Profile preview

dimenoxadol

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

Dimenoxadol is a synthetic opioid analgesic of the benzilic acid derivative class, structurally related to methadone and dextropropoxyphene. It produces typical opioid effects such as analgesia and sedation, along with side effects like dizziness and nausea. Dimenoxadol acts primarily as a mu-opioid receptor agonist. It was invented in Germany in the 1950s (some sources cite Russia in the 1960s) and has been used under the brand name Estocin in Russia. In the United States, it is classified as a Schedule I controlled substance due to its high potential for abuse and lack of accepted medical use[4][5][6].

Brand names
Estocin
Other names
dimenoxadoledimenossadolodimenoxadolum2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate
02

Targets

MOR (Mu opioid receptor)

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