dimeric naphthoquinone 3

**Dimeric naphthoquinone 3** is a naturally occurring small molecule isolated from the roots of *Diospyros lotus*. It is a dimeric naphthoquinone, specifically characterized as 8,5′,8′-trihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone. This compound exhibits **antiproliferative and cytotoxic effects** on mouse T-cell lymphoma cell lines, both parental and multidrug-resistant (MDR) variants, with notable activity against P-glycoprotein (ABCB1)–mediated MDR. The mechanism of action includes reversal of MDR and induction of cytotoxicity, likely via modulation of *P*-glycoprotein and apoptosis induction. It is part of a class of naphthoquinone dimers actively researched for their anticancer potential, especially as MDR modulators[1][3][6].

Other names

8,5′,8′-trihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone