dimetacrine

Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects. It was used in Europe and formerly in Japan for the treatment of depression. Dimetacrine acts as a non-selective monoamine reuptake inhibitor and likely shares pharmacological properties with other TCAs such as inhibition of serotonin and norepinephrine reuptake. Its mechanism also includes antagonism at acetylcholinesterase. The drug has been associated with cardiovascular side effects and abnormal liver tests; it may induce severe cardiac toxicity in overdose situations[1][2][4][5]. Dimetacrine is no longer widely marketed.

Brand names

IstonilIstonylLinostilMiroistonil

Other names

dimethacrineacripramine10-(3-(dimethylamino)propyl)-9,9-dimethylacridan10-[3-(dimethylamino)propyl]-9,9-dimethylacridanN,N,9,9-tetramethyl-10(9H)-acridinepropanamine