Drug intelligence / Profile preview

dimethandrolone undecanoate

Development stage
Phase 2
Lead developer
National Institute of Child Health and Human Development
Modality
Small Molecules
Administration
Oral, Intramuscular
01

Overview

Dimethandrolone undecanoate is an experimental oral and injectable androgen/anabolic steroid (AAS) and progestogen developed primarily as a potential male contraceptive. It acts as a prodrug of dimethandrolone, which is a potent agonist of both the androgen receptor and the progesterone receptor. By activating these receptors, it suppresses gonadotropin secretion (LH and FSH), leading to reversible suppression of sperm production in men. Unlike testosterone, it is not aromatized to estrogens or reduced by 5α-reductase, potentially reducing certain side effects such as prostate stimulation. The drug was developed by the Contraceptive Development Branch of the National Institute of Child Health and Human Development (NICHD), part of the US government[1][3][5][6].

Other names
Dimethandrolone undecylateDimethylnandrolone undecanoate7α,11β-Dimethyl-19-nortestosterone 17β-undecanoate7α,11β-Dimethylestr-4-en-17β-ol-3-one 17β-undecanoate
02

Targets

PR (Progesterone receptor)AR (Adrenergic receptors)

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