dimethyl amiloride

Dimethyl amiloride (DMA) is a potent small-molecule derivative of the diuretic amiloride, functioning primarily as an inhibitor of the sodium-hydrogen exchanger (NHE), specifically the NHE1 isoform. In the context of oncology research, DMA is frequently employed to block the biogenesis and secretion of exosomes, which are extracellular vesicles involved in cell-to-cell communication and drug resistance. Research indicates that DMA can reduce the viability of enzalutamide-resistant prostate cancer cells and enhance their sensitivity to treatment by disrupting exosome-mediated signaling and drug efflux. While its parent compound amiloride is used clinically for hypertension and edema, dimethyl amiloride is predominantly used as a pharmacological probe in preclinical studies and is widely available through research reagent vendors.

Other names

5-(N,N-dimethyl)amilorideN,N-dimethylamiloride5-(N,N-dimethyl)-amiloride