Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
dimethyl ampal thiolester
- Development stage
- Phase 2
- Lead developer
- Advanced BioDesign
- Modality
- Small Molecules
01
Overview
Dimethyl ampal thiolester (DIMATE) is a **small molecule inhibitor** of aldehyde dehydrogenases, specifically targeting ALDH1 and ALDH3 isoforms. It acts as a competitive, irreversible inhibitor of ALDH1, displaying major cytotoxic activity against human acute myeloid leukemia (AML) cell lines, particularly those enriched in leukemia stem cells (LSCs). Unlike conventional chemotherapy, DIMATE selectively eradicates AML LSCs while sparing healthy hematopoietic stem cells. This selectivity positions DIMATE as a promising novel agent for AML. It is under investigation for use in AML and related hematologic malignancies[1][3][5].
- Brand names
- Sefaldin
- Other names
- dimethylthioampal
02
Targets
ALDH1A1 (Aldehyde dehydrogenase 1 family member A1)ALDH3A1 (Aldehyde dehydrogenase 3 family member A1)
Beyond the preview
Go deeper on dimethyl ampal thiolester.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on dimethyl ampal thiolester.