Drug intelligence / Profile preview

dimethylaminopropionylphenothiazine

Development stage
Preclinical
Lead developer
Astra
Modality
Small Molecules
01

Overview

Dimethylaminopropionylphenothiazine is a synthetic phenothiazine derivative first synthesized in 1951 by Astra AG. It is classified as a small molecule and belongs to the phenothiazines, a group of polycyclic aromatic compounds. The compound has demonstrated anesthetic and antispasmodic activities in vivo, with its primary use described as an antispasmodic agent for functional gastrointestinal disorders. Its precise mechanism of action is not fully characterized, but it likely shares pharmacological properties with other phenothiazines, such as antagonism at histamine H1 receptors and possible antimuscarinic effects[2][5][6]. Dimethylaminopropionylphenothiazine remains experimental and does not have established clinical indications or widespread pharmaceutical use.

Other names
10-(alpha-dimethylaminopropionyl)phenothiazine10-(beta-dimethylaminopropionyl)phenothiazine2-(dimethylamino)-1-(10H-phenothiazin-10-yl)propan-1-one
02

Targets

mAChR (Muscarinic acetylcholine receptors)HRH1 (Histamine H1 Receptor)

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