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Drug intelligence / Profile preview
dimethyloxaloylglycine
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
Dimethyloxaloylglycine (DMOG) is a cell-permeable, competitive inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases (HIF-PH) and prolyl 4-hydroxylase (P4H). By mimicking hypoxia, DMOG prevents the hydroxylation of proline residues on HIF-1α and HIF-2α, thereby preventing their recognition by the von Hippel-Lindau (VHL) E3 ubiquitin ligase and subsequent proteasomal degradation. This leads to the stabilization and accumulation of HIF-1α, promoting the transcription of downstream target genes involved in angiogenesis, glycolysis, and cell survival, such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO). DMOG is widely utilized as a research tool to investigate cellular responses to hypoxia, ischemic injury, and tissue regeneration in preclinical models.
- Other names
- dimethyloxallyl glycinedimethyloxalylglycineDMOGN-(2-methoxy-2-oxoacetyl)glycine methyl esterN-(methoxyoxoacetyl)-glycine methyl ester
02
Targets
EGLN1 (Prolyl hydroxylase domain-containing protein 2)PHD1 (Prolyl hydroxylase domain-containing protein 1)PHD3 (Prolyl hydroxylase domain-containing protein 3)
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