dimetotiazine

Dimetotiazine is a small molecule drug belonging to the phenothiazine class, primarily used as an antimigraine agent and for its antiemetic and antihistamine properties. It acts as a serotonin receptor antagonist and histamine H1 receptor antagonist, blocking the effects of endogenous serotonin and histamine. This mechanism underlies its effectiveness in treating migraine, allergic skin conditions, nausea, vomiting (including that associated with chemotherapy), and other symptoms related to excessive serotonergic or histaminergic activity. Dimetotiazine has been marketed in Japan and Europe under brand names such as Fonazine and Migristene for the treatment of migraine disorders[3][4][7].

Brand names

FonazineMigristene

Other names

dimethothiazinedimetotiazine mesilatefonazine mesylatedimetotiazinumdimetotiazina