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Dingguiyou
- Development stage
- Unknown
- Lead developer
- Chengdu Shangke Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Dingguiyou is a Chinese patent medicine (CPM) developed by Chengdu Shangke Pharmaceutical Co., Ltd., primarily indicated for the treatment of irritable bowel syndrome (IBS), particularly the diarrhea-predominant subtype (IBS-D). It is a fixed-dose combination of clove oil (extracted from *Syzygium aromaticum*) and cinnamon oil (extracted from *Cinnamomum cassia*). The therapeutic efficacy of Dingguiyou is attributed to its primary bioactive constituents, eugenol and cinnamaldehyde, which exert antispasmodic, anti-inflammatory, and analgesic effects. The drug works by regulating gastrointestinal motility and reducing visceral hypersensitivity, often through the modulation of transient receptor potential (TRP) channels. It is typically formulated as soft capsules for oral administration and has been approved for marketing in China.
- Brand names
- Dingguiyou
- Other names
- Clove and Cinnamon OilDingxiang Rougui OilDingguiyou Soft Capsules
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPA1 (Transient receptor potential cation channel subfamily A member 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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