Dingji Fumai Decoction

Dingji Fumai Decoction is a traditional Chinese herbal medicine formula widely used in China for the treatment of arrhythmias, particularly ventricular premature contraction (VPC) and atrial fibrillation. The decoction consists of multiple herbs, including Ligusticum chuanxiong (Chuanxiong), Ziziphus jujuba Mill (Dazao), Poria cocos (Fuling), Cinnamomum cassia (Guizhi), Albizia julibrissin Durazz (Hehuanpi), Os Draconis (Longgu), Crassostrea gigas (Muli), Semen Ziziphi Spinosae (Suanzaoren), Polygala tenuifolia Willd. (Yuanzhi), and Glycyrrhiza uralensis Fisch. (Gancao)[1][4][7]. Clinical studies have shown that DFD can significantly reduce the frequency and severity of arrhythmias with good safety and patient compliance[6]. Mechanistically, DFD exerts antiarrhythmic effects through several pathways: - Suppression of sodium channel protein type 5 subunit alpha activity in a dose-dependent manner. - Modulation of Na+-K+-ATPase activity. - Regulation of connexin-43 expression. - Antioxidant effects by reducing malondialdehyde levels and increasing superoxide dismutase activity. - Reduction in cardiac oxidative stress and inflammation via upregulation of SIRT1 and downregulation of ACE, VCAM-1, IL-6[2][5]. DFD is considered to have class I antiarrhythmic properties due to its sodium channel blocking effect[2].

Brand names

Dingji Fumai Decoction

Other names

DFD丁己复脉汤