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Dingzhi Pills
- Development stage
- Unknown
- Lead developer
- Beijing Tong Ren Tang Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Dingzhi Pills (also known as Dingzhi Wan or Settle the Emotions Pill) is a classical Traditional Chinese Medicine (TCM) formula traditionally used to calm the mind, nourish the heart, and address emotional imbalances such as anxiety, insomnia, forgetfulness, and palpitations. Classically composed of four key herbal ingredients—*Radix Ginseng* (Ren Shen), *Sclerotium Poriae Cocos* (Fu Ling), *Rhizoma Acori Graminei* (Shi Chang Pu), and *Radix Polygalae Tenuifoliae* (Yuan Zhi)—the formula works synergistically to tonify Qi, resolve phlegm, and stabilize the spirit. In preclinical research, Dingzhi Pills have demonstrated antidepressant-like effects, which are mediated by modulating inflammatory responses (such as reducing TNF-α and IL-6 levels), regulating the AMPA/BDNF/TrkB/mTOR signaling pathway, and altering brain metabolism. Beijing Tong Ren Tang Chinese Medicine received a Proprietary Chinese Medicine Registration Certificate in Hong Kong in October 2026 for its proprietary formulation of Dingzhi Wan.
- Brand names
- Dingzhi Pills [Tong Ren Tang]Dingzhi Wan【Tong Ren Tang】
- Other names
- An Shen Ding Zhi WanDing Zhi WanDing Zhi Wu YouDing-Zhi-Xiao-WanKaixin WanSettle the Emotions Pill
02
Targets
HTR2A (Serotonin receptor 5-HT2A)AcetylcholinesteraseBDNF (Brain-derived neurotrophic factor)GRIA1 (AMPA receptor subunit GluA1)IL-6 (Interleukin 6)M1 (Muscarinic acetylcholine receptor M1)SERT (Sodium-dependent serotonin transporter)SYK (Spleen Tyrosine Kinase)NTRK2 (Tropomyosin-related kinase receptor type B)TPH2 (Tryptophan hydroxylase 2)TNFA (Tumor necrosis factor alpha (soluble))mTOR (Mammalian target of rapamycin kinase)
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