dinoprostone gel

0.5mg PGE2 gel is a specific formulation of dinoprostone (prostaglandin E2) gel, a small molecule prostaglandin analog used for cervical ripening and the induction of labor. The active ingredient, dinoprostone, is a naturally occurring prostaglandin that acts as an agonist on prostaglandin EP receptors (specifically EP1, EP2, EP3, and EP4) in the uterus and cervix. This action stimulates uterine contractions and promotes cervical softening and ripening by breaking down collagen. A well-known brand name for this formulation is Prepidil, which is administered endocervically. It is utilized in clinical settings, such as in trials evaluating early versus delayed induction of labor in patients presenting with prelabor rupture of membranes (PROM) at term.

Brand names

PrepidilProstin E2

Other names

0.5mg PGE2 geldinoprostone cervical geldinoprostone vaginal gelPGE2 gelPGE-2 gelPGE 2 gelprostaglandin E2 gel