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dioscin
- Development stage
- Unknown
- Modality
- Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Dioscin is a **natural steroid saponin** extracted from *Dioscorea nipponica* and other Dioscorea species. It has been used in traditional Chinese medicine and is an active pharmaceutical ingredient in Dioscin tablets for treating **coronary heart disease**, **coronary insufficiency**, and **hyperlipidemia**[1]. Dioscin exhibits **antitumor**, **antiviral**, **antifungal**, **anti-inflammatory**, **hepatoprotective**, and **antioxidant** effects and has shown benefit in studies for various cancers, metabolic disorders, and organ injuries[7][1][4]. Its mechanism involves induction of cancer cell apoptosis via oxidative stress, modulation of ATM/p53 signaling, and inhibition of various cellular signaling pathways (including MAPK, Erk1/2, P38, TOP1, EGFR, and VEGF2)[4][3][6]. Dioscin is also used as a precursor for steroid hormone synthesis, notably diosgenin’s glycoside derivative[1].
- Brand names
- Dioscin
- Other names
- dioscineioscincollettisideiiiPolyphyllin lllDioscin USP/EP/BP
02
Targets
EGFR (Epidermal growth factor receptor)ATM (Ataxia telangiectasia mutated protein)MAPK3 (Mitogen-activated protein kinase 1)MAPK14 (p38 mitogen-activated protein kinase alpha)PTPN6 (Protein tyrosine phosphatase non-receptor type 6)TOP1 (DNA Topoisomerase I)TP53 (Cellular Tumor Antigen p53 R175H)VEGFR2 (Vascular endothelial growth factor receptor 2)
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