Drug intelligence / Profile preview

diosgenin + vitamin D + alpha-lactalbumin

Development stage
Unknown
Lead developer
Lo.Li. Pharma
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Oral
01

Overview

Combination of **diosgenin**, **vitamin D**, and **alpha-lactalbumin**. Diosgenin is a bioactive steroidal sapogenin found in plants, known for its pleiotropic effects including anti-inflammatory, antioxidant, cholesterol-lowering, antiatherosclerotic, and antithrombotic actions. Mechanistically, diosgenin modulates endothelial function, reduces adhesion molecule expression, inhibits NF-κB signaling, regulates lipid metabolism through promotion of ABCA1-mediated cholesterol efflux, and inhibits inflammatory cytokine production[1][2]. Vitamin D is a secosteroid involved in calcium homeostasis, bone health, immune modulation, and anti-inflammatory responses. Alpha-lactalbumin is a major whey protein that facilitates nutrient absorption, especially steroids and metals (such as vitamin D), supports immune modulation, acts as a prebiotic, and may improve gut microbiota and bioavailability of nutrients[3]. The combined formula may have synergistic effects in supporting cardiovascular health, metabolic function, inflammation reduction, and possibly improved bioavailability of its components via alpha-lactalbumin.

02

Targets

TNFA (Tumor necrosis factor alpha (soluble))VDR (Vitamin D receptor)IL-6 (Interleukin 6)NF-κBGR (Glucocorticoid receptor)ABCA1 (ATP-binding cassette transporter A1)ESR1 (ERα)

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