Drug intelligence / Profile preview

dioxaphetyl butyrate

Development stage
Unknown
Lead developer
Winthrop Medicines
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Dioxaphetyl butyrate is a synthetic opioid analgesic and spasmolytic agent belonging to the diphenylacetic acid derivative class. It is structurally related to other open-chain opioids such as dextropropoxyphene and levacetylmethadol (LAAM). Dioxaphetyl butyrate acts as an agonist at opioid receptors in the central nervous system to produce typical opioid effects including analgesia (pain relief), euphoria, sedation, dependence liability, constipation, dizziness and nausea. It has no accepted medicinal use in the United States and is classified internationally as a controlled substance[1][3][5].

Brand names
AmidalgonSpasmoxal
Other names
dioxaphetyl butyrateethyl 4-morpholino-2,2-diphenylbutyrateethyl α,α-diphenyl-4-morpholinebutyrate4-morpholinebutanoic acid α,α-diphenyl-, ethyl ester4-morpholinebutyric acid α,α-diphenyl-, ethyl ester
02

Targets

MOR (Mu opioid receptor)

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