dioxidine

Dioxidine (hydroxymethylquinoxalinedioxide) is a synthetic, broad-spectrum antibacterial agent belonging to the quinoxaline 1,4-dioxide class. It has been used primarily in Russia and former Soviet countries for the treatment of severe purulent-inflammatory processes, including sepsis and peritonitis. In a clinical research context led by West Kazakhstan Marat Ospanov Medical University, dioxidine is being investigated as a metaphylactic treatment to prevent the recurrence of infection-related kidney stones (struvite stones) following percutaneous nephrolithotripsy (PCNL). The drug is administered via intrarenal instillation to target and eliminate residual bacterial colonization within the renal collecting system, which is a primary driver of stone formation. Its mechanism of action involves the inhibition of bacterial DNA synthesis and the induction of structural damage to the bacterial nucleoid, particularly under anaerobic conditions.

Brand names

Dioxydin

Other names

hydroxymethylquinoxalinedioxide2,3-bis(hydroxymethyl)quinoxaline 1,4-dioxide