Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
diphenhydramine + lorazepam + dexamethasone
- Development stage
- Unknown
- Lead developer
- University of South Florida
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination antiemetic therapy consisting of diphenhydramine, lorazepam, and dexamethasone, developed by the University of South Florida for the treatment of chemotherapy-induced nausea and vomiting (CINV) in pediatric patients. Administered via a continuous infusion pump (the 'BAD pump'), the regimen combines an antihistamine, a benzodiazepine, and a corticosteroid to provide both continuous and on-demand relief. Diphenhydramine acts as a histamine H1 receptor antagonist, lorazepam as a GABA-A receptor positive allosteric modulator, and dexamethasone as a glucocorticoid receptor agonist. This multi-targeted approach aims to improve emetic control compared to standard therapies like ondansetron in children receiving moderately or highly emetogenic chemotherapy.
- Other names
- BAD regimenBAD combination
02
Targets
GABRR (GABA-A receptor subunit rho)GR (Glucocorticoid receptor)HRH1 (Histamine H1 Receptor)GABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)
Beyond the preview
Go deeper on diphenhydramine + lorazepam + dexamethasone.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on diphenhydramine + lorazepam + dexamethasone.