Drug intelligence / Profile preview

diphenhydramine + phenylephrine + cocoa + dextromethorphan

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination drug containing four active ingredients: - **Diphenhydramine** is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergic symptoms such as sneezing, runny nose, and watery eyes. It also has sedative properties and can be used to relieve cough caused by minor throat or airway irritation[1][7]. - **Phenylephrine** is a sympathomimetic decongestant that acts primarily on alpha-adrenergic receptors to constrict blood vessels in the nasal passages, reducing swelling and congestion[1][2][6]. - **Dextromethorphan** is an antitussive (cough suppressant) that acts on the cough center in the brain to reduce the urge to cough[4][5]. - **Cocoa** is not recognized as an active pharmaceutical ingredient for cold or allergy medications; it may be included for flavoring or other non-pharmacological purposes. This combination would theoretically provide relief from symptoms associated with allergies, colds, or flu—including runny nose, sneezing, itchy/watery eyes, nasal congestion, sinus pressure, and cough—by combining antihistaminic (diphenhydramine), decongestant (phenylephrine), and antitussive (dextromethorphan) effects. Cocoa does not contribute any known pharmacological effect relevant to these indications.

Brand names
Dr. Cocoa
Other names
diphenhydramine and phenylephrinedextromethorphan, diphenhydramine, and phenylephrine
02

Targets

NaV (Voltage-gated sodium channels)mAChR (Muscarinic acetylcholine receptors)ADRA1A (α1A)HRH1 (Histamine H1 Receptor)

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