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Drug intelligence / Profile preview
diphenhydramine + zolpidem
- Development stage
- Phase 3
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular, Topical, Rectal
01
Overview
Di **Diphenhydramine + zolpidem** is a combination of two pharmaceutical drugs: diphenhydramine and zolpidem. Diphenhydramine is a first-generation H1 receptor antagonist (antihistamine) primarily used for treating allergies and as an over-the-counter sleep aid due to its sedative properties. Zolpidem is a non-benzodiazepine hypnotic that acts as a GABA-A receptor agonist and is FDA approved for the short-term treatment of insomnia. When combined, these drugs significantly increase central nervous system depression, leading to enhanced sedation, dizziness, and risk of confusion, especially in older adults. No unique branded combination exists under this name; their co-administration is generally discouraged due to a high risk of adverse effects[1][2][4].
- Other names
- diphenhydramine / zolpidem
02
Targets
GABRR (GABA-A receptor subunit rho)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)
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