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diphtheria, tetanus, and acellular pertussis vaccine (Changsheng Bio-technology)

Development stage
Discontinued
Lead developer
Changchun Changsheng Biological Products
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This is a combined prophylactic vaccine developed by Changchun Changsheng Biological Life Science Institute to provide immunity against diphtheria, tetanus, and pertussis. The vaccine utilizes an acellular pertussis component, which contains purified antigens rather than whole-cell bacteria, to reduce the incidence of adverse reactions. It was a key part of the Chinese National Immunization Program until 2018, when a major manufacturing scandal involving falsified data and substandard batches led to the revocation of the company's licenses and its subsequent bankruptcy. The vaccine is formulated with aluminum hydroxide as an adjuvant and is administered via intramuscular injection.

Other names
Acellular Pertussis, Diphtheria, Tetanus Combined Vaccine吸附无细胞百白破联合疫苗
02

Targets

Diphtheria toxinFHA (Filamentous hemagglutinin)

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