Drug intelligence / Profile preview

diphtheria, tetanus, and whole-cell pertussis vaccine + hepatitis B vaccine + haemophilus influenzae type b vaccine + meningococcal A and C vaccine

Development stage
Unknown
Lead developer
Parent
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This is a **6-in-1 combination vaccine** containing **diphtheria toxoid**, **tetanus toxoid**, **whole-cell pertussis vaccine** (killed Bordetella pertussis bacteria), **hepatitis B vaccine** (recombinant HBsAg), **Haemophilus influenzae type b (Hib) vaccine** (typically Hib polysaccharide conjugated to a carrier protein like tetanus toxoid), and **meningococcal A and C vaccine** (polysaccharides from Neisseria meningitidis serogroups A and C, often conjugated). It induces active immunity by stimulating production of protective antibodies against these six pathogens, preventing invasive diseases like diphtheria (respiratory infection), tetanus (lockjaw from Clostridium tetani toxin), pertussis (whooping cough), hepatitis B (viral liver infection), Hib meningitis/sepsis, and meningococcal A/C disease. Administered intramuscularly to infants as part of routine immunization schedules, it reduces the number of injections needed; whole-cell pertussis component provides robust but more reactogenic immunity compared to acellular versions.

02

Targets

NmA CPS (Neisseria meningitidis group A capsular polysaccharide)HBsAg (Hepatitis B surface antigen)Neisseria meningitidis group C capsular polysaccharideDiphtheria toxin

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