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diphtheria toxoid + tetanus toxoid + acellular pertussis vaccine + hepatitis B vaccine + haemophilus influenzae type b conjugate vaccine (Sanofi)
- Development stage
- Unknown
- Lead developer
- Parent
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
DTaP-HB-PRP~T vaccine is a pentavalent combination vaccine developed by Sanofi Pasteur for pediatric immunization. It is designed to provide simultaneous protection against five major infectious diseases: diphtheria, tetanus, pertussis (whooping cough), hepatitis B, and Haemophilus influenzae type b (Hib) infection. The vaccine formulation combines diphtheria and tetanus toxoids, acellular pertussis antigens (DTaP), recombinant hepatitis B surface antigen (HBsAg), and the Hib capsular polyribosyl-ribitol-phosphate (PRP) conjugated to a tetanus toxoid carrier (PRP~T). This combination is particularly intended for use in regions following the WHO Expanded Program on Immunization (WHO-EPI) schedule, where it can be co-administered with the oral polio vaccine (OPV) to reduce the number of required injections. Phase 3 clinical trials have evaluated its immunogenicity and safety as both a primary series and a booster dose in infants and toddlers.
- Other names
- DTaP-HB-PRP~T vaccinepentavalent DTaP-HB-Hib vaccinediphtheria + tetanus + acellular pertussis + hepatitis B + haemophilus influenzae type b conjugate vaccine
02
Targets
FHA (Filamentous hemagglutinin)HBsAg (Hepatitis B surface antigen)Poliovirus capsid proteinsPRNP (Cellular Prion Protein)ETV6 (ETS variant transcription factor 6)Diphtheria toxinFimbrial antigen type 3PRN (Pertactin)
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