diphyllin

Diphyllin is a natural arylnaphthalide lignan extracted from several tropical plants, notably Cleistanthus collinus and Justicia gendarussa, with a history of use in traditional Chinese medicine. It is a potent and selective inhibitor of vacuolar (H^+^) ATPase (V-ATPase), interfering with endosomal acidification essential for viral entry and replication. Diphyllin exhibits broad-spectrum antiviral activity against numerous enveloped RNA and DNA viruses, including tick-borne encephalitis virus, West Nile virus, Zika virus, Rift Valley fever virus, rabies virus, herpes simplex virus type 1, and has also been tested against Ebola virus and SARS-CoV-2. In oncology, diphyllin inhibits V-ATPase in cancer cell lines, impacting mTORC1/HIF-1α/VEGF signaling and suppressing proliferation, angiogenesis, and metastasis. Diphyllin generally shows low cytotoxicity in mammalian cells at effective concentrations.

Other names

9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-oneUNII-W4PN5LDP26UNII-W-4PN5LDP26UNII-W 4PN5LDP26