Drug intelligence / Profile preview

diploid wheat hull extract

Development stage
Preclinical
Lead developer
Colorado State University
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intraperitoneal
01

Overview

Diploid wheat hull extract is a botanical extract derived from the fibrous hulls of ancestral diploid wheat species (such as *Triticum monococcum* or einkorn) of Middle Eastern origin. Developed by researchers at Colorado State University, the extract has been investigated for its potential chemopreventive and anti-cancer properties, particularly against breast cancer. In vitro studies have demonstrated that the extract, which is rich in unique small-molecule metabolites, can significantly inhibit the proliferation of both estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) human breast cancer cell lines, whereas extracts from domesticated tetraploid and hexaploid wheat varieties show little to no inhibitory effect.

Other names
ancestral diploid wheat hull extractancestral wheat hull extract

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