diprophene

Diprophene is a synthetic small molecule anticholinergic and antispasmodic agent that was primarily developed and utilized in the Soviet Union. Chemically identified as the β-dipropylaminoethyl ester of diphenylacetic acid, it belongs to the same chemical class as adiphenine but features propyl substitutions. It functions as a dual antagonist of muscarinic (M-cholinolytic) and nicotinic (N-cholinolytic) acetylcholine receptors, providing both antispasmodic effects on smooth muscle and vasodilatory properties. Historically, diprophene was clinically indicated for peripheral vascular disorders such as endarteritis obliterans and Raynaud's disease, as well as for relieving spasms in the gastrointestinal and urinary tracts. Research from the 1950s and 1960s also explored its potential to lower blood cholesterol and inhibit the progression of atherosclerosis by facilitating the removal of lipids from the arterial walls.

Brand names

Diprophen

Other names

DiprophenumDiprofene2-(dipropylamino)ethyl diphenylacetate