Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
diprotin A
- Development stage
- Unknown
- Modality
- Small Molecules, Peptides
01
Overview
Diprotin A (isoleucine-proline-isoleucine) is a naturally occurring tripeptide that acts as a competitive inhibitor of dipeptidyl peptidase 4 (DPP-4, also known as CD26). Originally isolated from *Bacillus cereus*, it is widely utilized as a research tool to study the regulation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are crucial for glucose homeostasis. In addition to its role in metabolic research, diprotin A is investigated for its ability to enhance the homing and engraftment of hematopoietic stem cells and progenitor cells by preventing the degradation of stromal cell-derived factor-1 (SDF-1/CXCL12) by DPP-4. It has also been studied in the context of fungal infections, where it is exported in extracellular vesicles by *Cryptococcus* species and modulates fungal physiology and pathogenesis.
- Other names
- ILE-PRO-ILEIPIisoleucine-proline-isoleucineL-isoleucyl-L-prolyl-L-isoleucine
02
Targets
DPP-4 (Dipeptidyl Peptidase-IV)
Beyond the preview
Go deeper on diprotin A.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on diprotin A.