diptoindonesin G

Diptoindonesin G is a natural resveratrol dimer, a type of stilbenoid, originally isolated from plants such as those in the *Hopea* genus. It is being investigated as a potential therapeutic agent for prostate cancer, including castration-resistant (CRPC) and enzalutamide-resistant forms. The compound's primary mechanism of action involves promoting the proteasomal degradation of the androgen receptor (AR) and polo-like kinase 1 (PLK1). This degradation is mediated through the modulation and activation of the C-terminus of HSC70-interacting protein (CHIP), also known as STUB1, which is an E3 ubiquitin ligase. By reducing the protein levels of these key oncogenic drivers, Diptoindonesin G inhibits cell viability and tumor growth. Preclinical studies have demonstrated that it can also enhance the efficacy of HSP90 inhibitors and enzalutamide in human prostate cancer models.