dipyrone + chlorpheniramine maleate + phenylephrine hydrochloride

The combination of dipyrone (metamizole), chlorpheniramine maleate, and phenylephrine hydrochloride is a multi-ingredient pharmaceutical formulation used for the symptomatic relief of the common cold, influenza, and related upper respiratory tract infections. Primarily marketed in regions such as Brazil, this combination provides a triple therapeutic approach: **dipyrone** acts as a non-opioid analgesic and antipyretic by inhibiting prostaglandin synthesis; **chlorpheniramine maleate** is a first-generation antihistamine that reduces symptoms such as sneezing, rhinorrhea, and watery eyes by antagonizing histamine H1 receptors; and **phenylephrine hydrochloride** is a sympathomimetic decongestant that acts as an alpha-1 adrenergic receptor agonist to constrict blood vessels in the nasal passages, thereby reducing congestion. This specific triple combination is most commonly found in oral solution or liquid drops formulations, whereas capsule versions of similar brands often substitute dipyrone with paracetamol or acetylsalicylic acid.

Brand names

ResfenolMultigripCimegripeGriponia

Other names

metamizole + chlorpheniramine + phenylephrinedipirona + clorfeniramina + fenilefrinadipyrone + chlorphenamine + phenylephrine