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DIR-RGD-NP
- Development stage
- Preclinical
- Lead developer
- Yale University
- Modality
- Peptides, Nanoparticles → Drug Delivery Systems
- Administration
- Intraperitoneal
01
Overview
DIR-RGD-NP is an experimental tumor-targeting optical enhancer designed to aid in the intra-operative detection of ovarian cancer micrometastases. It consists of a deep infrared (DiR) fluorescent dye encapsulated within a poly(lactic-co-glycolic acid) (PLGA) nanoparticle. The surface of the nanoparticle is functionalized with the arginine-glycine-aspartate (RGD) peptide sequence, which specifically binds with high affinity to alpha-V beta-3 integrins overexpressed in tumor-associated neovasculature. By targeting the vasculature surrounding small tumor implants, DIR-RGD-NP allows for the visualization of lesions smaller than 1 mm, potentially improving the efficacy of surgical debulking and reducing microscopic residual disease.
- Other names
- DiR-RGD-PLGA-NPRGD-coated PLGA nanoparticles encapsulating DiR
02
Targets
αVβ5 (Integrin αVβ5)αVβ3 (Integrin αVβ3)ITGA5:ITGB1 (Integrin α5β1)
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