Drug intelligence / Profile preview

diractin

Development stage
Phase 3
Lead developer
IDEA
Modality
Small Molecules
Administration
Topical
01

Overview

Diractin is a topical pharmaceutical preparation containing ketoprofen (22.9 mg/g) formulated as a gel for dermal administration. It was developed for the symptomatic treatment of inflammation and pain associated with osteoarthritis. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins involved in inflammation and pain signaling[6][10]. The application for marketing authorization in Europe was withdrawn due to insufficient demonstration of efficacy at the proposed dose[6].

Brand names
Diractin
Other names
ketoprofen 22.9mg gelketoprofen22.9mg gelketoprofen-22.9mg gel
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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