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Drug intelligence / Profile preview
Disaccharide tripeptide glycerol dipalmitoyl
- Development stage
- Phase 2
- Lead developer
- ImmunoTherapeutics
- Modality
- Small Molecules
01
Overview
Disaccharide tripeptide glycerol dipalmitoyl (DTP-GDP) is a synthetic lipophilic disaccharide tripeptide derivative of muramyl dipeptide (MDP) with immunomodulatory activity. It stimulates macrophage activity and increases serum levels of various cytokines, including tumor necrosis factor alpha (TNF alpha), interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, and IL-12, potentially activating host immune system antitumor functions. It may be packaged in liposomes for improved delivery.
- Brand names
- ImmTher
- Other names
- N-acetylglucosamine-N-acetylmuramyl-alanyl-isoglutaminyl-alanyl-glycerol dipalmitoylL-alanine, N-(N-acetyl-4-O-(2-(acetylamino)-2-deoxy-β-D-glucopyranosyl)muramoyl)-L-alanyl-D-α-glutaminyl-, (2R)-2,3-bis((1-oxohexadecyl)oxy)propyl ester
02
Targets
IL1A (Interleukin 1 alpha)IL1B (Interleukin-1 beta)IL12 (Interleukin-12)IL-6 (Interleukin 6)IL8 (C-X-C Motif Chemokine Ligand 8)TNFA (Tumor necrosis factor alpha (soluble))
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