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disitamab vedotin + cisplatin + toripalimab
- Development stage
- Unknown
- Lead developer
- RemeGen
- Modality
- Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
This combination therapy consists of disitamab vedotin, cisplatin, and toripalimab. Disitamab vedotin is a HER2-targeted antibody-drug conjugate (ADC) composed of a humanized anti-HER2 monoclonal antibody conjugated to the microtubule-disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Cisplatin is a platinum-based chemotherapeutic agent that induces DNA cross-linking, leading to apoptosis. Toripalimab is a humanized IgG4 monoclonal antibody that targets the programmed cell death protein 1 (PD-1) receptor, blocking its interaction with PD-L1 and PD-L2 to restore T-cell mediated anti-tumor immune responses. This triplet regimen is being investigated, particularly in China by institutions like Beijing Anzhen Hospital, as a neoadjuvant or systemic treatment for patients with HER2-expressing urothelial carcinoma to maximize tumor shrinkage and improve survival outcomes through synergistic targeted cytotoxicity and immune activation.
- Brand names
- AidexiTuoyi
- Other names
- RC48 + Cisplatin + JS001
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)ERBB2 (Erb-b2 receptor tyrosine kinase 2)DNA
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