Drug intelligence / Profile preview

disodium cromoglycate + histamine dihydrochloride

Development stage
Unknown
Modality
Small Molecules
Administration
Inhalation, Oral, Topical, Subcutaneous, Ophthalmic, Intranasal
01

Overview

This is a combination of disodium cromoglycate (a mast cell stabilizer) and histamine dihydrochloride. Disodium cromoglycate inhibits degranulation of mast cells, preventing the release of histamine and other inflammatory mediators. It's used to treat mastocytosis, asthma, and allergic conditions. Histamine dihydrochloride is used in the treatment of acute myeloid leukemia and as a topical analgesic. The specific therapeutic purpose of this combination is not well documented in the available literature.

Other names
cromolyn sodium + histamine dihydrochloridecromoglycate + histamine dihydrochloride
02

Targets

HRH1 (Histamine H1 Receptor)HRH2 (Histamine H2 Receptor)GPR35 (G-protein Coupled Receptor 35)HSP90AA1 (Heat shock protein HSP90-alpha)S100P (S100 calcium-binding protein P)

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