disorazol Z

Disorazol Z is a highly cytotoxic **tubulin-binding macrodiolide polyketide** of the disorazole natural product family, originally isolated from myxobacteria and further developed preclinically by Aeterna Zentaris as AEZS-137 for oncology applications.[3][6][8][9][10] It binds to tubulin, disrupts microtubule dynamics, and causes mitotic arrest and apoptosis, showing sub-nanomolar antiproliferative activity in a broad range of tumor cell lines and potent antitumor effects in preclinical models.[3][8][9][10] The disorazole Z subclass, with disorazol Z1 as the main component, has activity comparable to disorazole A1 and is being explored both as a free cytotoxic agent and as a payload scaffold for targeted cancer therapies.[7][9][10]

Other names

disorazole Z