Drug intelligence / Profile preview

disoxaril

Development stage
Unknown
Lead developer
Sterling Winthrop
Modality
Small Molecules
01

Overview

Disoxaril is a synthetic small molecule antiviral agent belonging to the phenol ether class. It was developed as an inhibitor of human picornaviruses, including rhinoviruses and enteroviruses. Disoxaril acts by binding to a hydrophobic pocket within the viral VP1 capsid protein, thereby preventing the structural transitions required for viral uncoating and inhibiting viral replication. The compound has been studied primarily in experimental settings and is not approved for clinical use[1][2]. Its primary molecular target is the genome polyprotein of picornaviruses.

Other names
5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methyl isoxazoleDisoxarilum87495-31-6CS-0034714CS0034714CS 0034714NS00068545NS-00068545NS 00068545C06496C-06496C 06496D03874D-03874D 03874
02

Targets

VP1 (Picornaviral capsid protein VP1)

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