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DISP-11

Development stage
Preclinical
Lead developer
Dispatch Bio
Modality
Oncolytic Viruses → Oncolytic Therapeutics, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
01

Overview

**DISP-11** is an investigational sequential combination immunotherapy developed by Dispatch Bio for gastrointestinal cancers and other epithelial-origin solid tumors. It combines **DV-10**, a tumor-specific virus from Dispatch's Flare platform that systemically delivers a universal synthetic antigen to tumor cells and remodels the tumor microenvironment, with **zevorcabtagene autoleucel** (zevor-cel), an autologous B-cell maturation antigen-targeted CAR-T cell therapy supplied by CARsgen. The intended strategy is to prime tumor cells with DV-10 and subsequently administer zevor-cel, enabling CAR-T recognition and destruction of Flare-marked tumor cells. Dispatch lists DISP-11 as preclinical; a Phase 1 study in China has been planned. ([dispatchbio.com](https://dispatchbio.com/pipeline/))

Other names
DV-10 + zevor-cel
02

Targets

BCMA (B-cell maturation antigen)

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