dithiodesmethyl carbodenafil

Dithiodesmethyl carbodenafil is a synthetic small molecule analogue of sildenafil (Viagra) that acts as a phosphodiesterase-5 (PDE-5) inhibitor. It is not an approved pharmaceutical drug but is frequently identified as an undeclared illegal adulterant in dietary supplements marketed for male sexual enhancement. Structurally, it features a thiocarbonyl-thiolactam skeleton and shares the same pharmacological mechanism as approved PDE-5 inhibitors, which involves increasing cyclic guanosine monophosphate (cGMP) levels to promote smooth muscle relaxation and increased blood flow to the corpus cavernosum. Its presence in supplements poses significant health risks, particularly the potential for life-threatening hypotension when combined with nitrates. The FDA has issued multiple warnings and recalls for products containing this compound.

Other names

dithio-desmethyl-carbodenafildithiodesmethylcarbodenafil